Simply put, before we can truly achieve media literacy, we need to be self-literate. This involves moving beyond the ‘content’ of who we are and becoming knowledgeable as to what and how we are as a complex system. The ‘what’ can be understood as the structure or cartography of relations that constitute our selves, and the ‘how’ is the process of our mediated constitution. Both give rise to a system of becoming that is continually emergent and complex. Media technologies are a part of this process and are also affected by—and affect—the other constituting relations in our lives. In order to comprehensively understand media literacy, I develop a posthuman approach that consists of an intrasubjective mediating framework developed in this chapter along with a pragmatic instrument that leverages the framework in the next chapter.