This chapter discusses the requirements for adult fly rearing, high-volume egg production, larval rearing and pupariation, and it explains the production of disinfected medicinal maggots for maggot therapy, the quality control procedures that are required to ensure safe and efficacious maggot therapy, and supply chain management considerations arising from the perishability of medicinal maggots. The chapter draws on a broad range of sources including the literature on maggot therapy, forensic entomology, and general entomology. For compromised healthcare settings with limited resources, point-of-care production solutions are discussed that do not rely on sophisticated laboratory and logistics infrastructure.